pI: 8.944 |
Length (AA): 1047 |
MW (Da): 121720 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 491 | 4u1d (C) | 7 | 491 | 30.00 | 0 | 1 | 0.736873 | -0.26 |
674 | 846 | 5cwg (A) | 2 | 194 | 28.00 | 0.19 | 0.98 | 0.520834 | -1.09 |
791 | 854 | 5wsu (C) | 782 | 848 | 44.00 | 0.25 | 0.11 | 0.620727 | -1.9 |
792 | 854 | 3v6i (B) | 46 | 109 | 35.00 | 0.98 | 0.05 | 0.617772 | -2.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128741)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G11420 | eukaryotic translation initiation factor 3A |
Babesia bovis | BBOV_IV005090 | translation initiation factor 3 subunit 10, putative |
Brugia malayi | Bm1_29045 | eukaryotic translation initiation factor 3 subunit 10, putative |
Candida albicans | CaO19.6345 | translation initiation factor eIF3 |
Candida albicans | CaO19.13701 | translation initiation factor eIF3 |
Caenorhabditis elegans | CELE_C27D11.1 | Protein EGL-45 |
Cryptosporidium hominis | Chro.50354 | hypothetical protein |
Cryptosporidium parvum | cgd5_390 | putative eukaryotic translation initiation factor 3 |
Dictyostelium discoideum | DDB_G0272078 | eIF-3 theta |
Drosophila melanogaster | Dmel_CG9805 | CG9805 gene product from transcript CG9805-RD |
Echinococcus granulosus | EgrG_000738200 | eukaryotic translation initiation factor 3 |
Echinococcus multilocularis | EmuJ_000738200 | eukaryotic translation initiation factor 3 |
Homo sapiens | ENSG00000107581 | eukaryotic translation initiation factor 3, subunit A |
Loa Loa (eye worm) | LOAG_12041 | eukaryotic translation initiation factor 3 subunit 10 |
Loa Loa (eye worm) | LOAG_12797 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14815 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15533 | hypothetical protein |
Mus musculus | ensembl-mmu:ENSMUSG00000024991 | eukaryotic translation initiation factor 3, subunit A |
Neospora caninum | NCLIV_023050 | eukaryotic translation initiation factor 3 subunit 10, putative |
Oryza sativa | 4326038 | Os01g0120800 |
Plasmodium berghei | PBANKA_1428700 | eukaryotic translation initiation factor 3 subunit A, putative |
Plasmodium falciparum | PF3D7_1212700 | eukaryotic translation initiation factor 3 subunit A, putative |
Plasmodium knowlesi | PKNH_1432100 | eukaryotic translation initiation factor 3 subunit A, putative |
Plasmodium vivax | PVX_123340 | eukaryotic translation initiation factor 3 subunit 10, putative |
Plasmodium yoelii | PY04546 | eukaryotic translation initiation factor 3 subunit 10 |
Saccharomyces cerevisiae | YBR079C | Rpg1p |
Schistosoma japonicum | Sjp_0300070 | ko:K03254 translation initiation factor eIF-3 subunit 10, putative |
Schistosoma mansoni | Smp_001170 | eukaryotic translation initiation factor 3 subunit 10 (theta) |
Schmidtea mediterranea | mk4.001846.07 | Eukaryotic translation initiation factor 3 subunit A |
Schmidtea mediterranea | mk4.000912.08 | Eukaryotic translation initiation factor 3 subunit A |
Toxoplasma gondii | TGME49_201680 | eukaryotic initiation factor-3 subunit 10, putative |
Theileria parva | TP01_0235 | eukaryotic translation initiation factor 3 subunit 10, putative |
Trichomonas vaginalis | TVAG_385550 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C27D11.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C27D11.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C27D11.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C27D11.1 | Caenorhabditis elegans | sterile | wormbase |
YBR079C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_201680 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.